Eighty games is the standard suspension for a first-time offender.
Cano tested positive for the diuretic Furosemide, which violates the MLB's Joint Drug Prevention and Treatment Program.
While the Mariners had not announced a timetable for Cano's recovery, he could face surgery and was likely to miss at least several weeks with the injury.
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"Furosemide is used to treat various medical conditions in the United States and the Dominican Republic". "He has explained to us what happened, accepted the punishment and has apologized to the fans, the organization and his teammates".
In 39 games this season, the Dominican native was slashing.304/.354/.441 with four home runs, 23 runs batted in, and a 129 wRC+.
The 35-year-old is now nursing a broken hand which he suffered Sunday when he was hit by a pitch while playing against the Detroit Tigers. "We will support Robinson as he works through this challenge", the Mariners said in a statement. Cano hadn't missed a game this season and hasn't played in fewer than 150 games in any of the past 11 seasons.