That goal buoyed Spurs after the break but they were unable to convert their new-found vigour into goals, with City continuing to create the clearer chances.
Despite completely dominating the first-half, there were some nervy moments as Tottenham got back into the match until Raheem Sterling scored City's decisive third.
"City were good from the beginning and were more aggressive than us".
But they wasted no time in shutting up their critics and were 2-0 up by just the 25th minute as they cruised to a 3-1 win which ended Spurs' record of 14 games unbeaten. An exciting finale to the 2017/18 Premier League season beckons...
The way Guardiola and his players celebrated this win showed how much the PL success means and how relieved they were to get back to winning ways.
Manchester United (-475) had some starters nicked-up during the recent worldwide break, but it has won its last four home matchups, while Swansea City (+1300, draw +500) has generated little offense on the road all season.
A week ago, after losing 3-2 in the derby having relinquished a two-goal lead, there was doom-and-gloom around the Etihad Stadium and that misery was compounded three days later by City's Champions League quarterfinal exit against Liverpool.
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Rookie Jack Roslovic, replacing injured veteran Mathieu Perreault, had two assists in the game that ended with a series of fights. A lot of their young players had huge games (Ivan Provorov had two points; Nolan Patrick and Travis Konecny both scored goals).
De Bruyne, a player-of-the-year candidate and arguably the driving force behind the title charge, admitted after this game that better defending and resilience were important following a hard run.
Sane nearly scored City's third goal on 29 minutes only to be denied by Davinson Sanchez who raced back to block the German's effort.
Just before the goal came up, the visitors had tried Spurs keeper a couple of times but Lloris had no problem dusting Kevin De Bruyne's effort just four minutes into the game.
A week after spoiling City's title party, United duly handed the league to their local rivals. For example, first league in my club Barcelona was a dream come true and to come here in this stadium and win the Champions League against United was also so, so nice, especially the way we played. "It's incredible. They have been unbelievable".
"Now we have, in front of us, the most important title by far".
Despite going two down earlier in the game, Mauricio Pochettino's men were not going to give up the fight that early as they were also in the search to reduce the deficit before the end of the first half.
"The Champions League is seven knockout games".
"These guys are fantastic and awesome", said Guardiola, who will be on the golf course with his son when United plays on Sunday.