Barbara Bush, the wife of former US President George HW Bush, is in "failing health" and has made a decision to no longer seek medical treatment, the office of the ex-president says in a statement.
Bush's office released a statement, confirming after a "recent series of hospitalizations", she has decided against seeking additional medical help and will instead focus on "comfort care".
"Barbara and I are so sorry we can't be there for your Inauguration on January 20th", Bush wrote at the time.
The spokesman said Bush is "surrounded by a family she adores" and appreciates the messages and prayers she's received.
Bush, who served as president from 1989 to 1993, has a form of Parkinson's disease and uses a motorized scooter or a wheelchair for mobility.
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Barbara has also been a fierce protector and advocate for her family, most recently, helping her son, former Florida governor Jeb Bush, with his presidential campaign in 2016.
Bush, 92, is battling Chronic Obstructive Pulmonary Disease and congestive heart failure and has been hospitalized several times over the a year ago.
He did not elaborate as to the nature of Mrs Bush's health problems. He also served as a congressman, Central Intelligence Agency director and Ronald Reagan's vice president. She married at age 19 while George Bush was a young naval aviator.
Barbara Pierce Bush was born in Rye, New York.
She has dedicated her life post-White House life to the cause of literacy, and she and her husband have raised more than a billion dollars for charity since they left office.