England slumped to their third successive defeat and their lowest position in the Six Nations for 12 years as Ireland became only the second side to secure a grand slam at Twickenham since France in 1981, but Eddie Jones insists his side is moving forward.
Jonathan Joseph returns at outside centre, while Ben Te'o takes the place of Farrell at No12.
Knee injuries to Nathan Hughes and Courtney Lawes see Sam Simmonds and James Haskell start, while captain Dylan Hartley is restored at hooker. The second-row, who featured on the British and Irish Lions tour last summer, has been deployed at blindside flanker this season with Maro Itoje and Joe Launchbury playing at lock, and it further deepens England's back-row concerns given they are running out of experienced Test options.
"We need to get on the front foot against Ireland and we've selected a team to do that", said Jones. I think Ireland are worthy champions of a fantastic competition but it's a big game for us. The Ireland backline has been functioning well with Sexton the ring master.
"We can't wait to get back to Twickenham and play there", added Jones following succesive away defeats by both Scotland and France.
Yet, it's still surprising to hear that Eddie Jones invited one of the match officials for Saturday's clash with Ireland to referee England's training session on Tuesday.
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"So for us it has been an enormously beneficial tournament if disappointing because we are finding out about how to be a better team".
We're working very hard, looking at the detail, the before and after the breakdown.
Footage from a sponsored event of the England head coach in which he said "scummy Irish" and described Wales as a "little sh*t place" emerged today.
Coach Neal Hatley has said he has been drilling a pack of "angry" forwards this week as England look to put a stop to their poor form.
Following last week's 22-16 loss to France in Paris, Jones made seven changes in personnel - the most radical shake-up of his reign as England coach. We all belong to the Team of Us.
Schmidt's side have already wrapped up the Championship with a game to spare but, while Jones may have provided the extra motivation they needed for their trip across the Irish Sea, he believes the allure of claiming just their third men's Grand Slam in history is all the motivation they need.