In the Champions League, United have not faced a Spanish team since the 2013-14 when they played against Real Sociedad in the group stage.
United manager Jose Mourinho had said in his pre-match news conference that the French worldwide would return to the side after a poor run of form in the past few weeks.
Much of the build-up to the match from United's perspective was dominated by Pogba, with Jose Mourinho strongly refuting recent claims that he and the Frenchman had fallen out.
Eight-times winners Tottenham, who also needed a replay against fourth-tier Newport in the fourth round, could have few complaints at not finishing the tie.
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Mourinho said he took every available first-team player to Huddersfield Town for the FA Cup fifth-round tie on Saturday and was forced to supplement the squad with youngsters Ethan Hamilton and Angel Gomes.
With that in mind, it seems like a flawless time to analyse how have Manchester United fared against Spanish clubs in the past. 'Because we are going to lose Michael Carrick. "I also believe (that's the case) for Sheffield Wednesday - the same one more game", said Carvalhal who was given a warm reception on his return to the club he managed for two-and-a-half years.
'He was working normally with us before the game.
The goal took the sting out of the bubbly hosts and United proceeded to play the rest of the game out largely on their terms in a wholly comfortable final hour not in keeping with the opening 55 minutes. "Marcos Rojo, Phil Jones, Marouane, Zlatan - I don't think they have any chance, so we arrive at this crucial moment with some problems".
"Now people say a box-to-box has to play free of defensive duties". He was hauled off again in the 1-0 defeat by Newcastle United last weekend. Prior to the injury, the midfielder was one of the star players in his side's fixtures in the first four matches. With Pogba's absence in the starting eleven, it is up to Matic to be the physical presence Mourinho desires.