"We don't cry with injuries, we may cry with the process that leads to injures, but we don't cry".
Lukaku has been nursing an ankle injury but was sent on as a substitute by Roberto Martinez in the second half of Belgium's dead rubber World Cup qualifier against Cyprus.
"I don't know how he is", he said.
Filipe Luis was signed by Mourinho after his solid displays in Atletico Madrid's La Liga-winning campaign in 2013-14, but only spent one season at Stamford Bridge before returning to his old side having made just 15 appearances for the Blues.
Mourinho refused to blame worldwide action for leaving United a man short, adding: "Not just global teams, we don't only have injuries in worldwide teams".
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With Paul Pogba already out injured, midfielder Marouane Fellaini picked up an injury whilst on global duty with Belgium. "But last season we did not beat West Ham or Everton at home or Southampton away, so we are already six points better off".
He's become an important part of Mourinho's plans, but the Portuguese isn't anxious about players missing through injury.
Mourinho's United have been imperious in the Premier League so far this season, scoring 21 goals and conceding just twice.
"And [for] our way of thinking and feeling, it's no problem". "We trust every player. Now he is 100 per cent but we need to take into consideration that he has been with the group for only one session". However, they will be without midfield duo Paul Pogba and Marouane Fellaini for the trip to Anfield on Saturday.
The Red Devils are now second in the Premier League table and level on points with leaders Manchester City heading into their crunch clash with Liverpool this weekend.